English 4, post 3
Anticancer activity of new gold(III) complexes in colon cancer Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide. The limitations of cisplatin- based chemotherapy have prompted intense interest among scientists to search for alternative metal-based anticancer medicines. Cisplatin, which is one of the most widely used metal anticancer drugs, has been re- cognized as one of the most effective agents against colon cancer. However, cisplatin induces drug resistance, and its side effects still are major limitations to its clinical use. Among the non-platinum an- titumor agents, gold(IlI) complexes have been reported to exhibit cyto- toxicity against abroad spectrum of tumor cells, and their potencies are comparable with that of cisplatin. In recent years, a number of gold(III) complexes, such as porphyrins, have been reported to display potent anticancer activity. Among them, gold(III) tetraphenyl-porphyrin chloride [Au(TPP)]Cl is stable under physiological condi